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M94A3179.TXT
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Document 3179
DOCN M94A3179
TI HTLV-I/II infection among French blood donors.
DT 9412
AU Pillonel J; Courouce AM; Lemaire JM; Brunet JB; National Network of
Public Health, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):135 (abstract no. PA0158). Unique
Identifier : AIDSLINE ICA10/94369396
AB OBJECTIVES: 1) to determine the prevalence of HTLV-I/II antibodies among
French blood donors (BDs) since the beginning of the systematic
screening (15th July 1991) in Continental France (CF). 2) to study the
epidemiological characteristics of HTLV-I/II seropositive BDs. METHOD:
Since July 1991, the monitoring of HTLV-I/II mandatory screening
activity was organized in France. For each BD confirmed as HTLV-I/II
positive (Elisa + WB), the BT centers provided routinely informations on
age, sex and results of other mandatory tests (anti-HIV, HBsAg,
anti-HBc, anti-HCV) while informations on geographical origin and risk
factor were recorded through post-test interview. RESULTS: The
prevalence of HTLV-I/II per 10,000 blood donations was: TABULAR DATA.
SEE ABSTRACT VOLUME. From 1991 to 1993, all the 165 HTLV positive BDs
identified in overseas territories were HTLV-I. In CF, 5 were HTLV-II (1
born in Cameroon + 4 intravenous drug addicts) and 170 were HTLV-I.
Among the 170 HTLV-I found in CF, 50% were originating from CF, 38% from
the Caribbean, 5% from Africa, 2% from South-America and 5% from other
or unknown countries. Among the 85 BDs originating from CF, 79% had a
sexual partner from Caribbean. Due to previously targeted screening
policy and other mandatory tests, 49% of the infected units in CF would
have been discarded in the absence of universal screening. CONCLUSION:
HTLV prevalence is low in CF where the infection is mainly due to HTLV-I
(97%) and linked to endemic areas, mainly the Caribbean. As the
prevalence decreased between 1991 and 1993, the cost per avoided
contamination with the new screening policy went up from 1.34 to 4.24
million F. francs.
DE Age Factors *Blood Donors Blotting, Western Caribbean
Region/EPIDEMIOLOGY Comparative Study Enzyme-Linked Immunosorbent
Assay Female France/EPIDEMIOLOGY Hepatitis Antibodies/BLOOD
Hepatitis B Antibodies/BLOOD Hepatitis C Viruses Human HIV
Antibodies/BLOOD HTLV-I Antibodies/*BLOOD HTLV-I
Infections/BLOOD/DIAGNOSIS/*EPIDEMIOLOGY HTLV-II Antibodies/*BLOOD
HTLV-II Infections/BLOOD/DIAGNOSIS/*EPIDEMIOLOGY Male Prevalence Sex
Factors MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).